但是鼠抗独特型抗体，作为疫苗反复应用于人体可诱导人抗鼠抗体(human anti-mouse antibody,HAMA）的产生。同时抗独特型抗体只模拟少数表位，免疫原性弱，应用时还需要佐剂。
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...）批准上市，但是来源于鼠源淋巴细胞杂交瘤的抗体被人的免疫系统识别，会引起严重的人抗鼠抗体反应（human anti-mouse antibody,HAMA）,不仅使治疗性单抗半衰期变短，疗效减弱，有时还会引起严重的不良反应。
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Human anti-mouse antibody reaciton 人抗鼠抗体反应
human anti-mouse antibody response 人抗鼠抗体反应
Mouse Anti-Human Monoclonal Antibody 小鼠抗人单克隆抗体
以上来源于: WordNet
But at present, many anti idiotypic antibodies are mouse original antibodies, which can cause human anti mouse antibody (HAMA) response and decrease the curative effect.
但由于目前所使用的抗独特型抗体多为鼠源性，用于人体可产生人抗鼠抗体反应，从而影响疗效。
Results the detector plate only reacted with the anti-brucella antibody to show a specific reaction and showed no cross-reaction with anti-tubercle bacillus antibody or normal human and mouse samples.
结果本检测板只与有抗布氏菌抗体的样品有特异性反应，与正常人、兔和小鼠的样品以及有抗结核抗体的样品无交叉反应。
In order to reduce the human anti mouse antibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.
为了降低人抗鼠抗体反应，获得满意的免疫原性，将模拟人卵巢癌抗原的抗独特型单链抗体人源化。
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